Impaired survival and bacterial defense in LysM-<i>Myd88^−/−</i> and Tie2-<i>Myd88^−/−</i> mice.

<p>Control, LysM-<i>Myd88^−/−</i> and Tie2-<i>Myd88^−/−</i> mice were intranasally infected with ∼6×10³ CFU <i>K. pneumoniae</i>. Survival of control (dark grey symbols, n = 37), LysM-<i>Myd88^−/−</i> (light grey symbols, n = 9) and Tie2-<i>Myd88^−/−</i> mice (white symbols, n = 13) expressed as Kaplan-Meier plot <b>(A)</b>, bacterial loads in lung <b>(B)</b>, blood <b>(C)</b>, spleen <b>(D)</b> and liver <b>(E)</b>, of control (dark grey bars, n = 8), LysM-<i>Myd88^−/−</i> (light grey bars, n = 8) and Tie2-<i>Myd88^−/−</i> mice (white bars, n = 5 mice). Data are expressed as box-and-whisker diagrams depicting the smallest observation, lower quartile, median, upper quartile, and largest observation. BC+ = number of positive blood cultures. Survival curves were compared with Log-Rank test Bacterial loads were compared to control mice determined with Mann-Whitney <i>U</i> test: * <i>p</i><0.05, ** <i>p</i><0.01, *** <i>p</i><0.001.