Experiments and simulations of oxygen tension of tumors with wild-type, HIF-1<i>α</i>- and HIF-2<i>α</i>-deficient macrophages (WT, HIF-1<i>α</i> KO and HIF-2<i>α</i> KO).

<p>(a): Experimental data of oxygen tension (mmHg) against time (days). Red: WT; Blue: HIF-1<i>α</i> KO; Green: HIF-2<i>α</i> KO; (b): Same experiments aligned with tumor volumes (dots) and the correspondingly fitted curves; (c): Numerical simulations of oxygen tension against time; (d): Numerical simulations of oxygen tension aligned with tumor volumes.