Experiments and simulations of pH in tumors with wild-type, HIF-1<i>α</i>-, and HIF-2<i>α</i>-deficient macrophages (WT, HIF-1<i>α</i> KO, and HIF-2<i>α</i> KO).

<p>Horizontal axis represents time (in days) and vertical axis shows the pH value. (a): Experimental data of pH against time with error bars. Red: WT; Blue: HIF-1<i>α</i> KO; Green: HIF-2<i>α</i> KO. (b) – (d): Comparison of experiments (dots with error bars) and numerical simulations (dash curves) of pH in tumor with WT, HIF1-<i>α</i>, and HIF-2<i>α</i> KO macrophages, respectively.