Simulations of intracellular ROS concentration (first row) and tumor growth (second row) with different levels of GSH depletion in tumors with wild-type macrophages (left column) and HIF-1<i>α</i> KO macrophages (right column).

<p>Red: no depletion (); Green: moderate depletion (); Blue: severe depletion (). (a–b): ROS levels (<i>µ</i>M) against time (days); (c–d): the corresponding tumor volume (cm³).