The effect of recombinant HMGB1 on stimulating inflammatory cytokines and cell adhesion molecules.

<p>(A) Stimulating HMEC-1 cells with recombinant HMGB1 in control media for 2 hours induced the secretion of MCP-1 and IL-8 into the media (B) Exposure to recombinant HMGB1 also induced a moderate increase in ICAM-1. Normalized results are expressed as mean ± SEM, n = 3. *P<0.05 versus HMEC-1 cells cultured in control media. **P<0.01 versus HMEC-1 cells cultured in control media.