Average values and frequency distribution of peak Ca²⁺ release flux values in fibers from healthy volunteers and HF patients.

<p>Panel A shows the mean (±SD) of peak Ca²⁺ flux in fibers of healthy volunteers (hatched) and of HF patients (black) equilibrated with internal solution containing either 30∶15 or 20∶10 EGTA:Ca. Panel B shows the frequency distribution of peak Ca²⁺ release fluxes from all fibers in panel A. The binning width was 2.5 µM/ms and the lines correspond to fits of the data to standard normal distributions.