Histograms of seizure parameters in FVB.B6-<i>Sicd1/Sicd2</i> double congenic, and FVB.B6-<i>Sicd1/Sicd2</i>-ISCL1-ISCL-3 double sub-congenic mice following KA-induced status epilepticus.

<p>A. Data represent latency scores in minutes (mean ± SEM) for FVB.B6-<i>Sicd1/Sicd2</i> (n = 30), FVB.B6-<i>Sicd1/Sicd2</i>-ISCL1 (n = 14), FVB.B6-<i>Sicd1/Sicd2</i>-ISCL2 (n = 7), FVB.B6-<i>Sicd1/Sicd2</i>-ISCL3 (n = 14), and FVB-like littermate (n = 14) strains. ANOVA testing showed a significant reduction in latency (F_4,78 = 26.39; P<0.001) between all congenic strains and FVB-like littermates. B. Data represent the seizure duration scores in minutes (mean ± SEM) for FVB.B6-<i>Sicd1/Sicd2</i>, FVB.B6-<i>Sicd1/Sicd2</i>-ISCL1, FVB.B6-<i>Sicd1/Sicd2</i>-ISCL2, FVB.B6-<i>Sicd1/Sicd2</i>-ISCL3, and FVB-like littermate strains. ANOVA testing showed a significant increase in duration of severe seizures between FVB.B6-<i>Sicd1/Sicd2</i> and FVB-like littermates (F_1,43 = 4.87; P = 0.03) and between FVB.B6-<i>Sicd1/Sicd2</i>-ISCL3 and FVB-like littermates (F_1,27 = 4.93; P = 0.04).