Glucose tolerance and insulin sensitivity in <i>wt</i> and <i>dusp2^−/−</i> male mice after 4 and 12 weeks of diet.

<p>(<b>a</b> and <b>d</b>) oral glucose tolerance; (<b>b</b> and <b>e</b>) plasma insulin during the OGTT; and (<b>c</b> and <b>f</b>) plasma insulin area under the curve (AUC). * p&lt;0.05; Main Effect for HFD vs SCD. Data are mean ± SD. White squares are <i>wt</i> mice fed SCD; Black squares are <i>dusp2^−/−</i> mice fed SCD; White circles are <i>wt</i> mice fed HFD; Black circles are <i>dusp2^−/−</i> mice fed HFD. Ns are 5, 8, 8 and 8, for <i>wt</i> SCD, <i>dusp2^−/−</i> SCD, <i>wt</i> HFD and <i>dusp2^−/−</i> HFD, respectively.