Impaired anti-tumor immunity of STZ-diabetic CTLs.

<p>(A) Murine model of B16.gp33 melanoma with adoptive transfer of P14 CD8⁺ T effector cells. (B) After adoptive transfer of STZ-diabetic (n = 22) or STZ-non-diabetic (n = 21) P14 CD8⁺ T effector cells into B16.gp33 melanoma-bearing C57BL/6 mice, the survival time of the mice was recorded. Tumor-bearing mice with PBS but not T cells injection were considered as the controls (n = 20). (C) Tumor size of the mice that survived on day 30 after tumor inoculation. The increased fold of tumor size was calculated as tumor size at day 30 divided by that at day 7.