Anti-CD3+MK626 treatment temporarily reduced the CD4-to-CD8 distribution and enlarged the proportion of effector/memory T cells.

<p>(A) Frequency of CD4+ T cells (left panel) and CD8+ T cells (middle panel) as well as CD4-to-CD8 ratio (right panel) in spleens and PLN of new-onset diabetic NOD mice that remained protected for 2 and 7 weeks following each of the treatments. (B) Frequency of naïve (CD44loCD69-CD62L+), effector (CD44hiCD69+CD62L-) and memory (CD44hiCD69-CD62L+) T cell subsets in CD4+ (upper) and CD8+ (lower) gate from spleens and PLN of new-onset diabetic NOD mice that remained protected for 2 and 7 weeks following each of the treatments. Each dot represents an individual mouse. * vs. new-onset diabetic mice. One symbol p<0.05; two symbols p<0.01; three symbols p<0.001.