Venn diagram of DEGs associated with steatosis and phospholipidosis.

<p>Panel A: DEGs associated with phospholipidosis under all conditions (single dose at 3, 6, 9 and 24 h and repeated treatment (3, 7, 14 and 28 days) at the low, mid and high dose for 12 phospholipidosis drugs). Note, none of the DEGs were commonly regulated amongst phospholipidosis drugs. Panel B: DEGs common amongst phospholipidosis and steatosis drugs. By applying less stringent criteria (regulation in any of the conditions, either by dose or time) a total of 26 genes were commonly regulated. Panel C: PPI network among the 26 common genes. Of these 58% proteins interact with each other. The strength of association is depicted with the thickness of the blue line between the interacting proteins (STRING 9.1, confidence view).