Venn diagram of DEGs based on dose and time considerations.

<p>Panel A and B represent Venn diagrams of drug induced gene expression changes after single and repeated treatment at different doses and time points, respectively. For this purpose genes regulated at different doses (low, middle and high) and/or at least at three different time points (3, 6, 9 and/or 24 h) after single treatment were considered. The same analysis was carried out for animals treated repeatedly at the low, medium and high dose for 3, 7, 14 and 28 days. Panel C combines all DEGs after single and repeated dose/time considerations. Eventually, 9 genes were found to be regulated in common.