The rates of loss of heterozygosity at CHR3 in <i>top1</i>Δ backgrounds.

<p>A. The total rates of LOH events (5-FOA^R). <i>GTOP, or GBTM</i> indicates <i>pTET-lys2-GTOP</i> or <i>pTET-lys2-BTM</i> allele integrated in each of the strains analyzed. The 95% confidence intervals are indicated by the error bars. B. The rates of LOH initiating at <i>pTET-lys2-GTOP</i> or <i>pTET-lys2-BTM</i> cassette. LOH events are defined as initiating at <i>pTET-lys2-GTOP</i> or <i>pTET-lys2-BTM</i> cassette when <i>URA3</i> and G418^R are lost, only YJM789 sequence is present at <i>Sty</i>I, <i>BsrB</i>I, and <i>Spe</i>I SNP sites and both YJM789 and YPH45 sequence is present at <i>Nar</i>I and <i>Hind</i>III SNP sites (See <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004839#pgen.1004839.s009" target="_blank">Table S2</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004839#pgen-1004839-t002" target="_blank">Table 2</a> and <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004839#pgen-1004839-t004" target="_blank">Table 4</a>). P values were determined using the chi square analysis. *P = 0.014; **P = 0.0035; ***P<0.0001.