Histology of wild-type and transgenic mice.
- Isabel Paiva (686671)
- Rui M. Gil da Costa (686672)
- Joana Ribeiro (686673)
- Hugo Sousa (546270)
- Margarida Bastos (686674)
- Ana Faustino Carlos Rocha (686675)
- Paula A Oliveira (686676)
- Rui Medeiros (319600)
Publication date
January 2015
DOIAbstract
<p>a) Wild-type (-/-) female FVB/n mouse. Chest skin showing normal histology. H&E, 200x bar = 50μm b) K14-HPV16 transgenic (+/-) female FVB/n mouse. Chest skin showing epidermal hyperplasia and orthokeratotic hyperkeratosis. Note increased number of epidermal strata with conserved orderly squamous differentiation. c) K14-HPV16 transgenic (+/-) female FVB/n mouse. Ear skin showing in situ carcinoma. Note loss of epidermal stratification and progressive differentiation, presence of suprabasal mitotic figures and anisocytosis and abrupt parakeratotic keratinization with hyperkeratosis. The underlying stroma exhibits intense mixed inflammatory cell infiltration and neovascularization.</p
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