General histology demonstrating skin lesions of <i>Dhe/Dhe</i> mouse.

<p>(<b>A</b> and <b>C</b>) Wild-type trunkal skin sections illustrating well organized epidermis (E) and dermis (D), as well as anagen stage hair follicles extending through hypodermal fat (HF) region to the panniculus carnosus muscle (PC). (<b>B</b> and <b>D</b>) <i>Dhe</i>/<i>Dhe</i> trunkal skin sections exhibit a reduced hypodermal fat layer (double arrow in panels <b>A</b> and <b>B</b>), thickened epidermis, orthokeratotic hyperkeratosis, multinucleated keratinocytes in stratum spinosum (black arrow heads in panel <b>D</b>) and interfollicular epidermal pigmentation in dendritic cells (black arrow in <b>D</b>) and keratinocytes (white arrow in <b>D</b>). Apoptotic keratinocytes are scattered throughout stratum basale (white arrowhead in <b>D</b>). (<b>E</b>) <i>Dhe/Dhe</i> tail skin sections with large areas of dermal-epidermal separation (arrows). (<b>F</b>) Higher magnification image of boxed portion of panel <b>E</b> showing beginning of epidermal-dermal separation. (<b>G</b> and <b>H</b>) <i>Dhe/Dhe</i> trunkal skin section with shortened anagen phase hair follicles limited to dermis and hypoplastic sebaceous glands (arrow heads in panel H). (6 µm sections of 9-day-old mice; original magnifications shown in each panel).