Histological evidence of epidermal abnormalities in the aging Inv-Cldn6-CΔ196 transgenic epidermis.

<p>Histological evidence of epidermal abnormalities emerged in aging Inv-Cldn6-CΔ196 transgenic mice after 3 (<b>A</b>) and 6 (<b>B</b>) months as compared to the wild type. These included an expanded stratum corneum, as well as an expanded suprabasal zone and a less compacted granular layer suggesting an intrinsic propensity for injury and inefficient repair that increases with aging in the Inv-Cldn6-CΔ196 epidermis.