<p>Left boxplots show the average beta methylation levels over open-sea regions within an age-associated hypomethylated block on Chr-10 in normal tissue and age-matched cancers from the TCGA. (<b>A)</b> Endometrial Cancer (UCEC), <b>B)</b> Lung Adenoma Carcinoma (LUAD), <b>C)</b> Breast Cancer, <b>D)</b> Lung Squamous Cell Carcinoma (LSCC). P-values in boxplots are from a Wilcoxon rank sum test. Number of samples in each group is indicated. Right panel depicts the density distribution of the t-statistics of all age-hypomethylated blocks (magenta), as assessed between normal and age-matched cancer tissue. The cyan curve represents the corresponding statistics for a random set of non-age associated blocks, matched for number and length distri...
<p>All tumors were classified as either having “significant” or “slight” hypomethylation based on th...
<p>a) Boxplot displaying methylation levels at TTE-MBD2 binding sites in MCF-7 and HMEC compared to ...
Volcano plots representing both cell-type proportions adjusted and unadjusted limma models for each ...
<p>(A) Age-associated CpGs (ρ > 0.5 or ρ < -0.5) were identified in datasets of TCGA for normal cont...
<p><b>A)</b> Boxplots of mRNA expression levels in cord blood and placenta samples, for three sets o...
Cancer is an aging-associated disease but the underlying molecular links between these processes are...
DNA methylation is an epigenetic mechanism known to affect gene expression and aberrant DNA methylat...
na ar at olo the earliest stages [1]. Later studies identified CpG island hypermethylation as well [...
Cancer is an aging-associated disease, but the underlying molecular links between these processes ar...
<p><b>A)</b> Example of a large genomic region on chromosome-19 containing a significant age-associa...
<p><b>A.</b> Genes commonly methylated in >95% of all samples.</p><p><b>B.</b> Genes methylated in a...
<p><b>A.</b> Relative methylation frequency (% methylation in tumor minus % methylation in adjacent ...
Alterations in methylation are widespread in cancers. DNA methylation of promoter-associated CpG isl...
<p>(A) <i>Alu</i> methylation levels are not different among the four groups of breast lesions. (B) ...
<p><b>A)</b> Left top panel depicts the age of the individuals from which the blood samples were tak...
<p>All tumors were classified as either having “significant” or “slight” hypomethylation based on th...
<p>a) Boxplot displaying methylation levels at TTE-MBD2 binding sites in MCF-7 and HMEC compared to ...
Volcano plots representing both cell-type proportions adjusted and unadjusted limma models for each ...
<p>(A) Age-associated CpGs (ρ > 0.5 or ρ < -0.5) were identified in datasets of TCGA for normal cont...
<p><b>A)</b> Boxplots of mRNA expression levels in cord blood and placenta samples, for three sets o...
Cancer is an aging-associated disease but the underlying molecular links between these processes are...
DNA methylation is an epigenetic mechanism known to affect gene expression and aberrant DNA methylat...
na ar at olo the earliest stages [1]. Later studies identified CpG island hypermethylation as well [...
Cancer is an aging-associated disease, but the underlying molecular links between these processes ar...
<p><b>A)</b> Example of a large genomic region on chromosome-19 containing a significant age-associa...
<p><b>A.</b> Genes commonly methylated in >95% of all samples.</p><p><b>B.</b> Genes methylated in a...
<p><b>A.</b> Relative methylation frequency (% methylation in tumor minus % methylation in adjacent ...
Alterations in methylation are widespread in cancers. DNA methylation of promoter-associated CpG isl...
<p>(A) <i>Alu</i> methylation levels are not different among the four groups of breast lesions. (B) ...
<p><b>A)</b> Left top panel depicts the age of the individuals from which the blood samples were tak...
<p>All tumors were classified as either having “significant” or “slight” hypomethylation based on th...
<p>a) Boxplot displaying methylation levels at TTE-MBD2 binding sites in MCF-7 and HMEC compared to ...
Volcano plots representing both cell-type proportions adjusted and unadjusted limma models for each ...