Sch B suppressed the cardiac morphological changes and DNA damage.

<p>Typical photomicrographs of heart tissue from group N (A), group V (B) and group Sch B (C–E). Cytoplasmic vacuolation and myofibrillar disorganization in the doxorubicin group were effectively attenuated Sch B treatment (haematoxylin and eosin ×200). (F–J) Representative photomicrographs of DNA damage 5 days after Dox injection. DNA damage detected by single cell gel electrophoresis assay (Comet assay) in cardiomyoctes of all groups at 200x magnification. (K–L) Quantification of cardiomyocyte DNA damage analyzed by digital imaging casp-software (<a href="http://casp.sourceforge.net/" target="_blank">http://casp.sourceforge.net/</a>). **<i>P <</i> 0.01 vs. group N mice; ^#<i>P <</i> 0.05 and ^##<i>P <</i> 0.01 vs. group V mice.