Sch B suppressed doxorubicin-induced cardiac functional loss.

<p>(A) Chemical structure of Sch B. (B–D) Mice were treated with a single dose of doxorubicin (20 mg/kg, i.p.) with or without pretreatment of Sch B, followed by analysis of cardiac function of the left ventricle by echocardiography as described in Materials and Methods. Each bar represents means ± S.E. (n = 3–5). **<i>P <</i> 0.01 vs. group N mice; ^#<i>P <</i> 0.05 and ^##<i>P <</i> 0.01 vs. group V mice.