Behavioral testing.

<p><b>A)</b> Negative geotaxis task and forelimb task times at p14 were similar amongst treatment groups in both sexes. NT female mice performed open field test slower than control females (#p = 0.04). Males: control n = 14, NT n = 10, TH n = 11, females: control n = 15, NT n = 10, TH n = 10. <b>B)</b> Y-Maze testing at p21 (Phase 1): NT males scored lower than controls (*p = 0.02) and both NT and TH females scored lower than controls (# p = 0.01 and ^ p = 0.002, respectively). <b>C)</b> Y-maze Phase 2 (p28). Both NT and TH mice entered blocked arm fewer times than controls (*p<0.001 and #p = 0.001, respectively). <b>D)</b> Y-Maze Phase 2, stratified by sex. NT and TH females entered into blocked arm fewer times than control females (*p = 0.02 and # p = 0.01, respectively). NT males entered blocked arm blocked arm fewer times than controls (* p = 0.02). Males: control n = 12, NT n = 11, TH n = 12, Females: control n = 11, NT n = 10, TH n = 11.