<p>The frequencies of each specific mutation at codon 12 of K-RAS in not acceptable (<i>NA</i>) or acceptable (<i>A</i>) mCRC tumor specimens compared to the corresponding online dataset (<b>A</b>) were not statistically different (p>.05). Mutation frequencies at the exons 18–21 of EGFR were statistically different only for the exon 20 between <i>NA</i> or <i>A</i> specimens versus the online dataset (<b>B</b>). X-axis: specific K-RAS or EGFR mutations, divided into <i>NA</i>, <i>A</i> and the online dataset samples; Y-axis: frequency distributions of mutated samples.</p
Abstract Background Because driver mutations provide ...
Abstract Background Because driver mutations provide selective advantage to the mutant clone, they t...
<p>Abbreviations: MIA = minimally invasive adenocarcinoma; MP = micropapillary; IMA = invasive mucin...
<p>Acceptable (<i>A</i>) and not acceptable (<i>NA</i>) tumor specimens with mutated (MUT) or wild-t...
<p><i>NA</i> = Not acceptable samples</p><p><i>A</i> = Acceptable samples</p><p>NSCL SM-EGFR DB = Da...
<p><i>NA</i> = Not acceptable samples</p><p><i>A</i> = Acceptable samples</p><p>Cosmic DB = Cosmic d...
<p>(<b>A</b>) The cumulative distribution of the somatic mutations identified on the targeted exons ...
The occurrence of specific mutations in (A) all tissues, (B) the pancreas, (C) the large intestine, ...
<p><b>(a)</b> Per-individual numbers, sorted from high to low, of somatic mutations falling in ZF po...
Statistical analysis of pathogenicity of somatic mutations in cancer Recent large-scale sequencing s...
Ras is frequently mutated in cancer, however, there is a lack of consensus in the literature regardi...
<p>A. Frequencies of detected mutations in different exons. B. Mutation distribution in exons. C. Mu...
<p>A. <i>PIK3CA</i> mutations. B. <i>KRAS</i> mutations. C. <i>NRAS</i> mutations. D. <i>BRAF</i> mu...
<p>(<b>A</b>) Pattern of gross copy number alterations measured as fraction of the genome altered by...
#<p>The <i>EGFR</i> mutation analysis by direct sequencing was not evaluable for three of the tumour...
Abstract Background Because driver mutations provide ...
Abstract Background Because driver mutations provide selective advantage to the mutant clone, they t...
<p>Abbreviations: MIA = minimally invasive adenocarcinoma; MP = micropapillary; IMA = invasive mucin...
<p>Acceptable (<i>A</i>) and not acceptable (<i>NA</i>) tumor specimens with mutated (MUT) or wild-t...
<p><i>NA</i> = Not acceptable samples</p><p><i>A</i> = Acceptable samples</p><p>NSCL SM-EGFR DB = Da...
<p><i>NA</i> = Not acceptable samples</p><p><i>A</i> = Acceptable samples</p><p>Cosmic DB = Cosmic d...
<p>(<b>A</b>) The cumulative distribution of the somatic mutations identified on the targeted exons ...
The occurrence of specific mutations in (A) all tissues, (B) the pancreas, (C) the large intestine, ...
<p><b>(a)</b> Per-individual numbers, sorted from high to low, of somatic mutations falling in ZF po...
Statistical analysis of pathogenicity of somatic mutations in cancer Recent large-scale sequencing s...
Ras is frequently mutated in cancer, however, there is a lack of consensus in the literature regardi...
<p>A. Frequencies of detected mutations in different exons. B. Mutation distribution in exons. C. Mu...
<p>A. <i>PIK3CA</i> mutations. B. <i>KRAS</i> mutations. C. <i>NRAS</i> mutations. D. <i>BRAF</i> mu...
<p>(<b>A</b>) Pattern of gross copy number alterations measured as fraction of the genome altered by...
#<p>The <i>EGFR</i> mutation analysis by direct sequencing was not evaluable for three of the tumour...
Abstract Background Because driver mutations provide ...
Abstract Background Because driver mutations provide selective advantage to the mutant clone, they t...
<p>Abbreviations: MIA = minimally invasive adenocarcinoma; MP = micropapillary; IMA = invasive mucin...