<p>The frequencies of each specific mutation at codon 12 of K-RAS in not acceptable (<i>NA</i>) or acceptable (<i>A</i>) mCRC tumor specimens compared to the corresponding online dataset (<b>A</b>) were not statistically different (p>.05). Mutation frequencies at the exons 18–21 of EGFR were statistically different only for the exon 20 between <i>NA</i> or <i>A</i> specimens versus the online dataset (<b>B</b>). X-axis: specific K-RAS or EGFR mutations, divided into <i>NA</i>, <i>A</i> and the online dataset samples; Y-axis: frequency distributions of mutated samples.</p
Abstract Background Because driver mutations provide ...
<p>Abbreviations: MIA = minimally invasive adenocarcinoma; MP = micropapillary; IMA = invasive mucin...
a. The graphical summary of somatic mutations of the 4 genes in molecular subtypes. All of the 190 t...
<p>Acceptable (<i>A</i>) and not acceptable (<i>NA</i>) tumor specimens with mutated (MUT) or wild-t...
<p><i>NA</i> = Not acceptable samples</p><p><i>A</i> = Acceptable samples</p><p>NSCL SM-EGFR DB = Da...
<p><i>NA</i> = Not acceptable samples</p><p><i>A</i> = Acceptable samples</p><p>Cosmic DB = Cosmic d...
<p>(<b>A</b>) The cumulative distribution of the somatic mutations identified on the targeted exons ...
The occurrence of specific mutations in (A) all tissues, (B) the pancreas, (C) the large intestine, ...
<p><b>(a)</b> Per-individual numbers, sorted from high to low, of somatic mutations falling in ZF po...
Statistical analysis of pathogenicity of somatic mutations in cancer Recent large-scale sequencing s...
Ras is frequently mutated in cancer, however, there is a lack of consensus in the literature regardi...
<p>A. Frequencies of detected mutations in different exons. B. Mutation distribution in exons. C. Mu...
<p>A. <i>PIK3CA</i> mutations. B. <i>KRAS</i> mutations. C. <i>NRAS</i> mutations. D. <i>BRAF</i> mu...
<p>(<b>A</b>) Pattern of gross copy number alterations measured as fraction of the genome altered by...
#<p>The <i>EGFR</i> mutation analysis by direct sequencing was not evaluable for three of the tumour...
Abstract Background Because driver mutations provide ...
<p>Abbreviations: MIA = minimally invasive adenocarcinoma; MP = micropapillary; IMA = invasive mucin...
a. The graphical summary of somatic mutations of the 4 genes in molecular subtypes. All of the 190 t...
<p>Acceptable (<i>A</i>) and not acceptable (<i>NA</i>) tumor specimens with mutated (MUT) or wild-t...
<p><i>NA</i> = Not acceptable samples</p><p><i>A</i> = Acceptable samples</p><p>NSCL SM-EGFR DB = Da...
<p><i>NA</i> = Not acceptable samples</p><p><i>A</i> = Acceptable samples</p><p>Cosmic DB = Cosmic d...
<p>(<b>A</b>) The cumulative distribution of the somatic mutations identified on the targeted exons ...
The occurrence of specific mutations in (A) all tissues, (B) the pancreas, (C) the large intestine, ...
<p><b>(a)</b> Per-individual numbers, sorted from high to low, of somatic mutations falling in ZF po...
Statistical analysis of pathogenicity of somatic mutations in cancer Recent large-scale sequencing s...
Ras is frequently mutated in cancer, however, there is a lack of consensus in the literature regardi...
<p>A. Frequencies of detected mutations in different exons. B. Mutation distribution in exons. C. Mu...
<p>A. <i>PIK3CA</i> mutations. B. <i>KRAS</i> mutations. C. <i>NRAS</i> mutations. D. <i>BRAF</i> mu...
<p>(<b>A</b>) Pattern of gross copy number alterations measured as fraction of the genome altered by...
#<p>The <i>EGFR</i> mutation analysis by direct sequencing was not evaluable for three of the tumour...
Abstract Background Because driver mutations provide ...
<p>Abbreviations: MIA = minimally invasive adenocarcinoma; MP = micropapillary; IMA = invasive mucin...
a. The graphical summary of somatic mutations of the 4 genes in molecular subtypes. All of the 190 t...