Sleep time is reduced and sleep fragmentation is increased in <i>Grm2/3</i>^-/- mice.

<p>Fig 1A-F depict immobility-determined sleep parameters derived from 3 separate days of video-tracking data. Fig 1G-I depict immobility-determined sleep parameters derived from 14 consecutive days of passive-infrared (PIR) data. (A & G) Average sleep profiles, (B & H) light phase sleep time, and (C & I) dark phase sleep time for <i>Grm2/3</i>^<b>+/+</b> and <i>Grm2/3</i>^<b>-/-</b> mice during a 12:12 h light/dark (12:12 LD) cycle at 100 lux. (D) Average temporal distribution of sleep bouts, (E) number of light phase sleep bouts, and (F) light phase sleep bout duration in <i>Grm2/3</i>^<b>+/+</b> and <i>Grm2/3</i>^<b>-/-</b> mice during 12:12 LD at 100 lux. Sleep was defined as a period of immobility of at least 40 s. Data in Fig 1A, D & G are presented in 2 h time bins. ZT = zeitgeber time. Note that methods do not yet exist to automatically compute parameters pertaining to the frequency and duration of sleep bouts from PIR data.