TgCRND8 mice show sleep-wake cycle disruption at early and advanced pathological stages.

<p>Hourly time courses (<b>A</b>) and cumulative percent duration (<b>B</b> and <b>C</b>) of wake, NREM and REM sleep across the light and dark phases at 3 (NTg n = 7, Tg n = 8), 7 (NTg n = 5, Tg n = 7) and 11(NTg n = 6, Tg n = 4) months of age. (<b>B)</b> During the dark phase, 3, 7 and 11-month-old TgCRND8 spend more time awake and less time in NREM sleep in comparison to NTg. Three and 7-month-old TgCRND8 mice also show a significant decrease in the percent time spent in REM sleep during the dark phase in comparison to NTg. (<b>C)</b> During the light phase, 3, 7 and 11-month-old TgCRND8 spend more time awake and less time in NREM sleep in comparison to NTg. Total time spent in REM sleep did not differ significantly between TgCRND8 and NTg during the light phase, at all ages studied. Error bars represent SEM. Panel <b>A</b> was analyzed by two-way ANOVA, followed by Bonferroni test for multiple comparisons. Panels <b>B</b> and <b>C</b> were analyzed by two-way ANOVA, followed by Tukey’s post-hoc test, * <i>P</i><0.05, ** <i>P</i><0.01, ***<i>P</i><0.001.