Baseline sleep/wake characterizations of WT and W/W^v mice.

<p>(A) Time course for amount of wake (top) and SWS (middle) was not different between the two genotypes. Amount of REM (bottom) was slightly decreased in W/W^v mice during the light phase (L; ZT0-12) but was not during the dark phase (D; ZT12-24). (B) EEG delta power in SWS was significantly higher in W/W^v mice during the light phase (L; ZT0-12). The bar graphs indicate the averaged data for each 12-hour period across ZT0-12 (L) and ZT12-24 (D). (C) Cumulative sleep/wake loss and gain compared with baseline conditions for the sleep deprivation experiment. Sleep deprivation began at ZT0 and ended at ZT6 (the shadow areas). (D) The rebound response of EEG delta power in SWS after sleep deprivation was attenuated in W/W^v mice. Data is expressed as the percent change from the baseline value (dotted line) at the same time. Amount of sleep/wake and EEG delta power was averaged at hourly intervals. *p < 0.05, **p < 0.01, WT versus W/W^v. All data is expressed as mean ± SEM (n = 8/group).