The enhanced cell migration and invasion induced by MCM were inhibited by smsDX.

<p>(A, C, E) Co-culture with MCM enhanced the cell migration of LNCaP, DU145 and PC-3 cells. SmsDX suppressed the effect of MCM. (B, D, F) The migration change is presented as the percentage of the initial distance between the two edges. (G, I, L) Transwell migration and invasion assay of LNCaP, DU145 and PC-3 cells treated with MCM and/or smsDX. (H, J, M) The LNCaP, DU145 and PC-3 cells that successfully migrated and invaded were counted. Data are presented as the means ± SD of three independent experiments. Data are presented as mean ± SD, *p<0.05, **p<0.01,#p<0.05,## p<0.01.