Pathways study of STS-induced altered proteins.

<p>Global Interaction Proteome of <b>(a)</b> STS treated cells and <b>(b)</b> B2I+STS treated cells. The green rectangles, violet rectangles and blue hexagons are reflective of biological processes, disease processes and functional classes, respectively. The different colors of proteins reflect their alteration: upregulated (red), downregulated (orange), downregulated and unique to the treated group (yellow). The green highlights represent the detrimental effects observed following STS or B2I+STS treatment and the pink highlight represents the protective effect observed following B2I+STS treatment. STS: Staurosporine, B2I: Bradykinin 2 receptor inhibited. Creatine kinase B-type [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0128601#pone.0128601.ref015" target="_blank">15</a>], designated by blue highlight is shown to be upregulated in the STS+ B2I treatment where cell survival pathway was detected.