Dynamic molecular network induced by KGF in skin SCC cells.

<p>KGF-treatment of skin SCC cells induces up- and downregulation of variety of ERK1/2-regulated genes including upregulation of <i>DUSP6</i>, <i>ETV5</i>, <i>SPRY1</i>, and <i>SPRY4</i> genes. KGF also induces downregulation of <i>MMP7</i>, <i>MMP13</i> and <i>CXCL10</i>. The data presented show KGF-induced changes as an average in three SCC cell lines. The image was generated using Ingenuity Pathways Analysis (IPA). The symbols represent gene function, as indicated in legend on the right. Red color indicates gene upregulation and green color downregulation by KGF. The genes with fold change >1.5 are indicated with the strongest red (up) and green (down) colors. The rainbow color indicates a group of genes with up- or downregulation. Some of the groups (FGF, MMP, MKP1/3/4) are “opened” to show the regulation of individual genes. The arrows and lines indicate direct (solid line) and indirect (dashed line) physical and functional interactions. The arrows show the direction of regulation. The relations found in this study are highlighted with yellow arrows.