<i>Pten</i> mutant prostates exhibit precious cytodifferentiation.

<p>Antibody staining of the luminal marker CK18 (green) on sections of P5 prostates show expression is increased mutant (B) prostatic ducts compared to controls (A). Red arrowheads indicate ducts. Antibody staining of the basal cell marker p63 on sections of P5 and P3 prostates shows expression is downregulated in the mutant ducts (D,F) compared to controls (C,E), indicated with black arrowheads. Antibody staining for pAKT and PTEN on sections of P3 prostates show a loss of PTEN (H) and an upregulation of pAKT (J) in mutant buds compared to controls (G,I).