Effect of JAK inhibitors, PF956980 and PF1367550 and dexamethasone on IFNγ and IFNγ + TNFα-stimulated release of CXCL9, CXCL10 and CXCL11 from BEAS-2B cells.

<p>BEAS-2B cells were pre-treated and incubated for 1h with either PF956980 (○), PF1367550 (●), or dexamethasone (▲) followed by stimulation for 20h with IFNγ (10ng/ml) (panels a-c) or IFNγ + TNFα (10ng/ml) (panels d-f). Media was harvested and the concentrations of CXCL9 (panels a and d), CXCL10 (panels b and e) and CXCL11 (panels c and f) were measured by ELISA. Data are presented as mean±SEM, n = 7–8.