Effect of JAK inhibitors, PF956980 and PF1367550 on IFNγ and IFNγ + TNFα-stimulated expression of <i>CXCL9</i>, <i>CXCL10</i>, and <i>CXCL11</i>.

<p>BEAS-2B cells were pre-treated with either PF956980 (checked bars), PF1367550 (hashed bars) or dexamethasone (10^-6M white bar) for 1h followed by stimulation with IFNγ (10ng/ml) or IFNγ + TNFα for 6 h. Gene expression of <i>CXCL9</i> (panels a and b), <i>CXCL10</i> (panels c and d) and <i>CXCL11</i> (panels e and f) were quantified by Taqman RT-PCR. Data are presented as fold change form stimulus ± SEM; n = 3 where 1 indicates the level of mRNA induced by IFNγ or IFNγ + TNFα in the absence of inhibitors.