Frequency of DMRs’ distances to closest Transcription Start Site and DMRs location distribution regarding genes and CpG islands.

<p>a) The distance from the transcription start site is represented in base pairs from the 0 in the x-axis b) The labels in both pies represent: inside, DMR contained within the feature; include feature, the genomic feature is entirely included in the DMR; overlap start, the DMR extend over the start site of the feature; overlap end, the ending site of the feature overlaps with the DMR; downstream, DMR locates downstream the feature; upstream, the DMR aligns upstream the genomic feature.