Effects of YM 022 on gastric acid secretion stimulated by motilin, and co-administration of motilin and ghrelin.

<p>Left and middle panels represent the gastric acid secretion (blue line) and pH (red line) changes at 10-min intervals after intravenous administration of vehicle/YM 022 (0.2 mg/kg BW) followed by pentagastrin (1 μg/kg BW) (A, B), motilin (10 μg/kg BW) (D, E) and co-administration of motilin and ghrelin (G,H) throughout the experiment. The net change in cumulative acid output for 50 min after administration of pentagastrin (C), motilin (F) and co-administration of motilin and ghrelin (I) with or without YM 022 pretreatment is shown in the right panels. Each value represents the mean ± SEM. <i>p</i> < 0.05 was considered statistically significant. YM: YM 022; PG: pentagastrin; G: ghrelin; M: motilin, figures after the abbreviations denote concentration in μg/kg. n = 3.