Effects of atropine on motilin, and co-administration of motilin and ghrelin-stimulated gastric acid secretion.

<p>Gastric acid secretion (blue line) and pH (red line) changes were monitored at 10-min intervals throughout the experiment. In the left and middle panels, intravenous administration of either vehicle or atropine (30 μg/kg BW) was done 30 min before carbachol (5 μg/kg BW) (A, B), motilin (10 μg/kg BW) (D, E) and co-administration of motilin and ghrelin (G,H) treatment. Right panels compare the net change in cumulative acid output for 50 min after administration of carbachol (C), motilin (F) and co-administration of motilin and ghrelin (I) with vehicle or atropine pretreatment. Each value represents the mean ± SEM. <i>p</i> < 0.05 was considered statistically significant. A: atropine; C: carbachol; G: ghrelin; M: motilin, figures after the abbreviations denote concentration in μg/kg. n = 3.