European Review for Medical and Pharmacological Sciences

gastric emptying. Because the effects of ghrelin can be studied in rodents, which do not respond to motilin because they are natural motilin recep-tor KOs, the mechanism of ghrelin’s prokinetic effects is already well understood. There is the involvement of ghrelin receptors on vagal affer-ents, in the nodose ganglion, in central nuclei in-volved in signaling information from the gas-trointestinal tract, and on myenteric neurons5. Their relative importance remains to be deter-mined. Because ghrelin and motilin, and their re-ceptors are structurally related, interaction with the motilin receptor could be considered, but is contrary to experimental evidence. Also, avail-able data suggest that under physiological condi