<p><sup>a</sup><i>T</i>. <i>b</i>. <i>rhod</i>.:<i>T</i>. <i>b</i>. <i>rhodesiense</i> strain STIB 900, trypomastigotes.</p><p><sup>b</sup>Cytotoxicity on L6 cells.</p><p><sup>c</sup>Selectivity index: IC<sub>50</sub> Cytotoxicity L6/ IC<sub>50</sub><i>T</i>. <i>b</i>. <i>rhodesiense</i>.</p><p>IC<sub>50</sub> values are means of two independent assays, which varied < ±50%.</p><p>In vitro activity against T.b. rhodesiense in IC50 (μM) of compounds fulfilling hit criteria.</p
<p><sup><i>a</i></sup>CC<sub>50</sub>: concentration of drug inducing 50% of cell growth arrest.</p>...
The cytotoxicity of prodigiosin, an antibiotic and potential trypanocide produced by Serratia marces...
When propagated in vitro bloodstream forms of all Trypanosoma brucei subspecies give suspension cult...
<p><sup>a</sup><i>T</i>. <i>cruzi</i>, strain Tulahuen C4, intracellular amastigotes.</p><p><sup>b</...
<p><sup><i>a</i></sup><i>P</i>. <i>falc</i>.: <i>P</i>. <i>falciparum</i> strain K1.</p><p><sup>b</s...
<p>Species names are abbreviated. T.B = <i>T.b. brucei</i>; T.R = <i>T.b rhodesiense</i>; L.D = <i>L...
<p><b>A)</b> Western blot analysis of cell extracts from 2x10<sup>7</sup> <i>T</i>. <i>b</i>. <i>bru...
Human African Trypanosomiasis (HAT) is caused by two trypanosome sub-species, Trypanosoma brucei rho...
Human African Trypanosomiasis (HAT) is caused by two trypanosome sub-species, Trypanosoma brucei rho...
Human African Trypanosomiasis (HAT) is caused by two trypanosome sub-species, Trypanosoma brucei rho...
<p><sup><i>a</i></sup><i>L</i>. <i>don</i>. axen.: axenic amastigotes of <i>L</i>. <i>donovani</i>, ...
All the compounds were assayed for their ability to inhibit adenosine uptake by the P2 transporter. ...
Various assays are in use to determine the effect of a drug on cells propagated in vitro. The trypan...
<p>* compounds with lower activity in at least one parasite species compared to L929.</p><p>Only mea...
All the compounds were assayed for their ability to inhibit adenosine uptake by the P2 transporter. ...
<p><sup><i>a</i></sup>CC<sub>50</sub>: concentration of drug inducing 50% of cell growth arrest.</p>...
The cytotoxicity of prodigiosin, an antibiotic and potential trypanocide produced by Serratia marces...
When propagated in vitro bloodstream forms of all Trypanosoma brucei subspecies give suspension cult...
<p><sup>a</sup><i>T</i>. <i>cruzi</i>, strain Tulahuen C4, intracellular amastigotes.</p><p><sup>b</...
<p><sup><i>a</i></sup><i>P</i>. <i>falc</i>.: <i>P</i>. <i>falciparum</i> strain K1.</p><p><sup>b</s...
<p>Species names are abbreviated. T.B = <i>T.b. brucei</i>; T.R = <i>T.b rhodesiense</i>; L.D = <i>L...
<p><b>A)</b> Western blot analysis of cell extracts from 2x10<sup>7</sup> <i>T</i>. <i>b</i>. <i>bru...
Human African Trypanosomiasis (HAT) is caused by two trypanosome sub-species, Trypanosoma brucei rho...
Human African Trypanosomiasis (HAT) is caused by two trypanosome sub-species, Trypanosoma brucei rho...
Human African Trypanosomiasis (HAT) is caused by two trypanosome sub-species, Trypanosoma brucei rho...
<p><sup><i>a</i></sup><i>L</i>. <i>don</i>. axen.: axenic amastigotes of <i>L</i>. <i>donovani</i>, ...
All the compounds were assayed for their ability to inhibit adenosine uptake by the P2 transporter. ...
Various assays are in use to determine the effect of a drug on cells propagated in vitro. The trypan...
<p>* compounds with lower activity in at least one parasite species compared to L929.</p><p>Only mea...
All the compounds were assayed for their ability to inhibit adenosine uptake by the P2 transporter. ...
<p><sup><i>a</i></sup>CC<sub>50</sub>: concentration of drug inducing 50% of cell growth arrest.</p>...
The cytotoxicity of prodigiosin, an antibiotic and potential trypanocide produced by Serratia marces...
When propagated in vitro bloodstream forms of all Trypanosoma brucei subspecies give suspension cult...