<p>Class-dependent post-spike dynamics of <b>A</b> conductance <i>g</i>, <b>B</b> <i>g</i>/<i>C</i> = 1/<i>τ</i>, <b>C</b> spike threshold <i>V</i><sub>T</sub> and <b>D</b> equilibrium potential <i>E</i>. Note the sag in the <i>E</i> dynamics of TL5 cells. <b>E</b> Quantifying <i>E</i> dynamics by jump and sag depth. <b>F</b> TL5 <i>E</i> dynamics in control conditions and after application of <i>I</i><sub><i>h</i></sub>-blocker ZD7288, which abolished the sag. <b>G</b> The blocker also resulted in a hyperpolarization of the steady-state rest, with a post-spike jump increase and sag-depth reduction.</p
Reduced neuron models are essential tools in computational neuroscience to aid understanding from th...
<p>A set of sample spikes from Type I and Type II neuron as d<i>V</i>/d<i>t</i> increases from 0.2mV...
<p>We present detailed models of pyramidal cells from human neocortex, including models on their exc...
<p>The four cell classes studied were <b>A</b> layer-2/3 (red), layer-4 (orange), slender-tufted lay...
<p>Quantifying heterogeneity in neocortical pyramidal-cell populations. The parameter groupings are:...
Models of neocortical networks are increasingly including the diversity of excitatory and inhibitory...
<div><p>Models of neocortical networks are increasingly including the diversity of excitatory and in...
Models of neocortical networks are increasingly including the diversity of excitatory and inhibitory...
<p>A) Schematic of this experiment with isolated pyramidal cells each receiving a unique train of Po...
<p><b>(a)</b> (Top) Different phenomenological models of a L5 pyramidal cell (left to right): the de...
<p>The frequency-current (f-I) profiles and an example of rebound firing of pyramidal cells are pres...
<p>(A) and (B) respectively give the sample subthreshold and suprathreshold responses of each cell t...
Pyramidal cells are the primary excitatory neurons in the cerebral cortex of the mammalian brain. Th...
In Section 1 of this supplement, we describe the process of constructing the pyramidal cell model. I...
<p><b>(A)</b> We performed patch-clamp recordings in layer 2/3 pyramidal neurons in vitro, in respon...
Reduced neuron models are essential tools in computational neuroscience to aid understanding from th...
<p>A set of sample spikes from Type I and Type II neuron as d<i>V</i>/d<i>t</i> increases from 0.2mV...
<p>We present detailed models of pyramidal cells from human neocortex, including models on their exc...
<p>The four cell classes studied were <b>A</b> layer-2/3 (red), layer-4 (orange), slender-tufted lay...
<p>Quantifying heterogeneity in neocortical pyramidal-cell populations. The parameter groupings are:...
Models of neocortical networks are increasingly including the diversity of excitatory and inhibitory...
<div><p>Models of neocortical networks are increasingly including the diversity of excitatory and in...
Models of neocortical networks are increasingly including the diversity of excitatory and inhibitory...
<p>A) Schematic of this experiment with isolated pyramidal cells each receiving a unique train of Po...
<p><b>(a)</b> (Top) Different phenomenological models of a L5 pyramidal cell (left to right): the de...
<p>The frequency-current (f-I) profiles and an example of rebound firing of pyramidal cells are pres...
<p>(A) and (B) respectively give the sample subthreshold and suprathreshold responses of each cell t...
Pyramidal cells are the primary excitatory neurons in the cerebral cortex of the mammalian brain. Th...
In Section 1 of this supplement, we describe the process of constructing the pyramidal cell model. I...
<p><b>(A)</b> We performed patch-clamp recordings in layer 2/3 pyramidal neurons in vitro, in respon...
Reduced neuron models are essential tools in computational neuroscience to aid understanding from th...
<p>A set of sample spikes from Type I and Type II neuron as d<i>V</i>/d<i>t</i> increases from 0.2mV...
<p>We present detailed models of pyramidal cells from human neocortex, including models on their exc...