Data set of CA1 pyramidal cell models using an intact whole hippocampus preparationV2

<p>The frequency-current (f-I) profiles and an example of rebound firing of pyramidal cells are presented. Four .abf files contain the f-I curve data for the respective cell (as labelled PYR1, PYR2, PYR3 and PYR4 for Pyramidal cell 1, Pyramidal cell 2, Pyramidal cell 3 and Pyramidal cell 4). That is, they contain the cell's response to the application of a series of depolarizing current steps of 1 s duration while the cells are held in current clamp, as well as the current clamp data itself. Each recording is 2 s total. Amplitudes of the input were increased incrementally with step sizes of 10 pA for PYR1, PYR3, and PYR4, and a step size of 25 pA for PYR 2. PYR1 first spikes on the 5th of 30 steps with 38.7 pA of depolarizing input. PYR2 first spikes on the 3rd of 13 steps with 1.2 pA of input. PYR3 first spikes on the 7th of 34 steps with 62.0 pA of input, and PYR4 first spikes on the 7th of 30 steps with 12.1 pA of input. In the .abf file labelled PYR5_rebound, an example of rebound firing of a pyramidal cell following hyperpolarizing input is given. While the cell was held at -52 mV in current clamp, as series of 1 s hyperpolarizing steps (10 steps, 25 pA increments) were used to record the post- hyperpolarization rebound spiking. For the figure showing this rebound spiking (Figure 1), the first two hyperpolarizing steps and the respective firing are shown. For visualization purposes, the spike artifact in the current clamp input trace was removed and replaced with the mean current in the Figure.