<p>Treatment with a miR-29a mimic and HDAC4 RNAi significantly deceased HDAC4 expression in the HSCs of WT mice. Data are expressed as the mean ± SE of four independent experiments. *indicates a p < 0.05 between the groups.</p
<div><p>(A) HDAC1 and IFNβ are regulated by influenza-induced miRNAs. Histograms illustrating the av...
<p>(<b>A</b>) Expression profiles in <i>miR-29</i>-treated N2a cells. MISSION microRNA Mimic (Sigma-...
<p>(<b>A</b>) Tumorigenicity in nude mice subcutaneously injected with CSCs from SPC-A1/DTX cells (5...
<p>A miR-29a mimic and HDAC4 RNAi significantly increased H3K9Ac and decreased both Smad3 and p-Smad...
<p>A miR-29a mimic or HDAC4 RNAi significantly inhibited the migration of primary HSCs of WT mice. D...
<p>A miR-29a mimic or HDAC4 RNAi inhibited the proliferation of primary HSCs. In addition, treatment...
<p>TLCA increased HDAC4 expression (A) and nuclear translocation (B) in HSCs of WT mice (white bar)....
<p>(A) Predicted putative (upper) and mutated (lower, shown in red) binding sequence in the 3’UTR of...
<p>MiR-29a is an important regulator of the profibrogenic phenotype of HSCs. By suppressing HDAC4 ac...
<p>Freshly isolated HSCs were transfected with siRNA after 24 hours of culture and a second time on ...
<p>(A) Sirius-Red staining showed moderate fibrosis in WT mice and mild fibrosis in miR-29aTg mice, ...
<p>(A) Infection of multipotential L2.3 cells with lentiviral-encoded shRNA specific for HDAC4 leads...
Recent studies have shown that microRNA-29 (miR-29) is significantly decreased in liver fibrosis and...
<p>IGROV-1 cells were transfected with 50 nmol/l hsa-miR-302b or a scrambled oligonucleotide and RNA...
<p>(a) HDAC4 protein levels were assessed 24hr after transfection of miR-206 inhibitor (hp-miR-206) ...
<div><p>(A) HDAC1 and IFNβ are regulated by influenza-induced miRNAs. Histograms illustrating the av...
<p>(<b>A</b>) Expression profiles in <i>miR-29</i>-treated N2a cells. MISSION microRNA Mimic (Sigma-...
<p>(<b>A</b>) Tumorigenicity in nude mice subcutaneously injected with CSCs from SPC-A1/DTX cells (5...
<p>A miR-29a mimic and HDAC4 RNAi significantly increased H3K9Ac and decreased both Smad3 and p-Smad...
<p>A miR-29a mimic or HDAC4 RNAi significantly inhibited the migration of primary HSCs of WT mice. D...
<p>A miR-29a mimic or HDAC4 RNAi inhibited the proliferation of primary HSCs. In addition, treatment...
<p>TLCA increased HDAC4 expression (A) and nuclear translocation (B) in HSCs of WT mice (white bar)....
<p>(A) Predicted putative (upper) and mutated (lower, shown in red) binding sequence in the 3’UTR of...
<p>MiR-29a is an important regulator of the profibrogenic phenotype of HSCs. By suppressing HDAC4 ac...
<p>Freshly isolated HSCs were transfected with siRNA after 24 hours of culture and a second time on ...
<p>(A) Sirius-Red staining showed moderate fibrosis in WT mice and mild fibrosis in miR-29aTg mice, ...
<p>(A) Infection of multipotential L2.3 cells with lentiviral-encoded shRNA specific for HDAC4 leads...
Recent studies have shown that microRNA-29 (miR-29) is significantly decreased in liver fibrosis and...
<p>IGROV-1 cells were transfected with 50 nmol/l hsa-miR-302b or a scrambled oligonucleotide and RNA...
<p>(a) HDAC4 protein levels were assessed 24hr after transfection of miR-206 inhibitor (hp-miR-206) ...
<div><p>(A) HDAC1 and IFNβ are regulated by influenza-induced miRNAs. Histograms illustrating the av...
<p>(<b>A</b>) Expression profiles in <i>miR-29</i>-treated N2a cells. MISSION microRNA Mimic (Sigma-...
<p>(<b>A</b>) Tumorigenicity in nude mice subcutaneously injected with CSCs from SPC-A1/DTX cells (5...