Structural Displacements Along Each of the Top Three PCs.

<p>Displacements of CAs along each of the three top PCs are visualized on the right by plotting the coordinates of each PC. The SI and SII regions are annotated to show that they undergo some of the largest internal fluctuations captured by PC1 and PC2. The displacements along each PC are visualized on the left on an H-Ras structure using Pymol [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004470#pcbi.1004470.ref044" target="_blank">44</a>]. The colored sections correspond to the switch regions of H-Ras, with SI in green and SII in blue. Sections colored in light green show regions with structural changes of a similar magnitude to the switch regions.