Structural flexibility of domains PSI, I-EGF-1, and I-EGF-2.

<p>(A) RMSF values calculated for each residue of the L33 (blue line) and the P33 (red line) forms of β3. Both structures show high flexibility. (B) Atom movements analyzed by PCA are projected on the first two modes. The P33 structure movements (red cloud of dots) are higher than that measured for the L33 structure (blue cloud of dots) for the first mode. No significant differences were observed for the second mode. The proline increased the structural flexibility of the PSI, I-EGF-1 and I-EGF-2 domains. The first and second modes represent 45% and 13% of the informativeness of the data.