<p>A-C: Confocal microscopic images of murine ear skin 6–24 hours after local intradermal inoculation. (A) Low magnification images of lymphatic vessels in skin and surrounding infected tissue 24 hours post infection (scale bar 20 μm). (B) 3D rendered images and (C) orthogonal views of the same z-stacks at 6 hours post infection. Arrows indicate individual streptococci interacting with LYVE-1 dense regions of lymphatic vessel endothelium (scale bar 5 μm). D-E: Epifluorescence microscopic images of frozen sections of draining cervical nodes 6 hours post infection at low power (100X magnification)(D) and high power (400X)(E) (Scale bar 50 μm and 20 μm respectively). Red = LYVE-1, green = GAS, blue = nuclei. Arrows indicate encapsulated GAS ad...
<p><b>A.</b> Overview image of the HF US platform for cervical lymph node evaluation. An anesthetize...
<p>A) Schematic illustration showing localization of mOrange2 positive lymphatic vessels in a <i>Cx4...
<p>(A) Bacterial colony forming unit (CFU) counts from the blood of mice grafted with human skin and...
<p>(A) Bacterial burden in LN (circles) and ears (triangles) harvested at 24 hpi from mice inoculate...
<p>Mice were inoculated with RFP-<i>Y. pestis</i> and the ear pinna was removed along with surroundi...
<p>(A, B) High-resolution confocal images of whole-mount skin preparations from E16.5 cKO (n = 3) an...
<p>Mice were infected with 1×10<sup>6</sup> Sterne strain or TKO spores subcutaneously in the left e...
<p><b>(</b>A) Generation of isogenic acapsular strains of M18 and M89 GAS. Left-right; Comparison of...
<p>(<b>a–c</b>) An inguinal LN was dissected and maintained at 37°C under superfused medium bubbled ...
An increased research focus on the lymphatic system has necessitated the development of reliable in ...
<p>Immunofluorescence staining of frozen sections of chronically inflamed skin (21 days after inflam...
<p>4-month-old TNF-Tg and WT mice received a footpad injection of DEFINITY® or saline, and were subj...
Major vessels in the neck of the mice injected with FDG-labeled erythrocytes could be visualized, su...
<p>(A, B) H&E-stained sections of formalin-fixed LN tissue from uninfected (A) and infected (B) anim...
<p>Whole mount staining of neonatal mouse diaphragm demonstrated colocalization of LYVE-1 positive l...
<p><b>A.</b> Overview image of the HF US platform for cervical lymph node evaluation. An anesthetize...
<p>A) Schematic illustration showing localization of mOrange2 positive lymphatic vessels in a <i>Cx4...
<p>(A) Bacterial colony forming unit (CFU) counts from the blood of mice grafted with human skin and...
<p>(A) Bacterial burden in LN (circles) and ears (triangles) harvested at 24 hpi from mice inoculate...
<p>Mice were inoculated with RFP-<i>Y. pestis</i> and the ear pinna was removed along with surroundi...
<p>(A, B) High-resolution confocal images of whole-mount skin preparations from E16.5 cKO (n = 3) an...
<p>Mice were infected with 1×10<sup>6</sup> Sterne strain or TKO spores subcutaneously in the left e...
<p><b>(</b>A) Generation of isogenic acapsular strains of M18 and M89 GAS. Left-right; Comparison of...
<p>(<b>a–c</b>) An inguinal LN was dissected and maintained at 37°C under superfused medium bubbled ...
An increased research focus on the lymphatic system has necessitated the development of reliable in ...
<p>Immunofluorescence staining of frozen sections of chronically inflamed skin (21 days after inflam...
<p>4-month-old TNF-Tg and WT mice received a footpad injection of DEFINITY® or saline, and were subj...
Major vessels in the neck of the mice injected with FDG-labeled erythrocytes could be visualized, su...
<p>(A, B) H&E-stained sections of formalin-fixed LN tissue from uninfected (A) and infected (B) anim...
<p>Whole mount staining of neonatal mouse diaphragm demonstrated colocalization of LYVE-1 positive l...
<p><b>A.</b> Overview image of the HF US platform for cervical lymph node evaluation. An anesthetize...
<p>A) Schematic illustration showing localization of mOrange2 positive lymphatic vessels in a <i>Cx4...
<p>(A) Bacterial colony forming unit (CFU) counts from the blood of mice grafted with human skin and...