KLF4 is not expressed in B cells but can reactivate lytic EBV gene expression in this cell type.

<p>A) Immunoblot analysis was performed to compare the levels of endogenous KLF4 expression in a series of EBV-infected epithelial cell lines and EBV-infected B cell lines. Actin served as a loading control. B) Raji Burkitt lymphoma cells were transfected with either control vector or a KLF4 expression vector and immunoblot analysis was performed to compare the levels of transfected KLF4 and lytic viral proteins Z, R and BMRF1. Actin served as a loading control. C) The levels of transfected KLF4 into Raji cells (from 11B) was compared to the endogenous levels of KLF4 in AGS-Akata cells.