Additional file 1: of Effect of oral administration of low-dose follicle stimulating hormone on hyperandrogenized mice as a model of polycystic ovary syndrome

CLUSTAL multiple sequence alignment scheme of β-FSH. Sequence matching of β-subunits of FSH in bovine, murine and human species and in comparison to the peptide sequence utilized in the in vitro assay. Asterisks indicate positions that have a fully conserved residue. (Clustal Omega: http://www.ebi.ac.uk/Tools/msa/clustalo/ ). Compared to the human sequence chosen for the peptide in vitro study, this segment in bovine FSH contains two different amino-acids. Neither of these amino acids residues affects the specific residues for hFSH-receptor binding as identified in literature [48]. (TIFF 393 kb