Additional file 2 of FAAP100 is required for the resolution of transcription-replication conflicts in primordial germ cells

Additional file 2: Fig. S2. Deletion of Faap100 results in premature ovarian insufficiency. A, Statistical analysis for genotyping results of pups resulting from the mating of heterozygous female mice with heterozygous male mice. n=218 pups. B, A representative photograph of 3-month-old wild-type and Faap100-/- female mice. C, Body weights of 3-month-old wild-type and Faap100-/- mice. n=11/11/8/8. D, Levels of FSH and E2 in the serum of 3-month-old wild-type and Faap100-/- female mice. FSH, n=9/8; E2, n=7/7. E, Estrous cycles of 3-month-old wild-type and Faap100-/- female mice. n=6/6. Representative data from 3 independent mice per genotype. E, estrus; P, proestrus; D, diestrus; M, metestrus. Data are shown as the mean ± SD (C, D). Chi-square test (A) and unpaired two-tailed Student’s t-test (C, D), ns, not significant and **P < 0.01