Extracellular acidosis upregulates glutamatergic synaptic transmission at cortical GABAergic neurons dominantly.

<p>Spontaneous EPSCs were recorded on GABAergic neurons by whole-cell voltage-clamp without stimulating presynaptic axons. <b>A)</b> shows the recorded sEPSCs under the control (top trace), intracellular acidification (middle trace) and extracellular acidification (bottom trace). <b>B)</b> illustrates the differences of sEPSC amplitudes between intracellular acidosis and control (∆EPSC amplitudes, red bar) as well as the differences between extracellular acidosis and control (∆EPSC amplitudes, blue bar; p<0.01, n = 15; one-way ANOVA). <b>C)</b> shows the differences of inter-sEPSC interval between intracellular acidosis and control (∆inter-IPSC interval, red bar) as well as the differences between extracellular acidosis and control (blue bar; p<0.01, n = 15; one-way ANOVA).