Post-transcriptional effect of IL-17A on chemokine production.
- Hirotaka Matsuzaki (673194)
- Yu Mikami (673193)
- Kousuke Makita (818682)
- Hideyuki Takeshima (818683)
- Masafumi Horie (379262)
- Satoshi Noguchi (491160)
- Taisuke Jo (673195)
- Osamu Narumoto (673196)
- Tadashi Kohyama (673197)
- Hajime Takizawa (673198)
- Takahide Nagase (379265)
- Yasuhiro Yamauchi (257179)
Publication date
October 2015
DOIAbstract
<p>To investigate the post-transcriptional effect of IL-17A, BEAS-2B cells were treated with actinomycin D 3 h after stimulation with poly(I:C) (2.5 μg/mL) with/without IL-17A (100 ng/mL). We plotted expression of CXCL8 and CXCL1 mRNA at 0, 30, 60, 120 and 180 min after actinomycin D addition. (A) The IL-17A and poly(I:C) co-stimulation group showed a continuously high level of CXCL8 mRNA expression even after actinomycin D addition, compared with the poly(I:C) alone group. (B) There was no significant difference in the level of CXCL1 mRNA after addition of actinomycin D in two groups. *: <i>p</i> < 0.05, compared to poly(I:C) alone. n = 3 independent experiments.</p
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