The hypothermic effect of carvacrol is lost at low ambient temperature of 10°C.

<p>(A) Adult male CD-1 mice were injected intravenously with vehicle or carvacrol at 50 mg/kg at time 0 and transferred to the temperature-controlled chamber with an ambient temperature set to 10°C. Core temperature of mice was measured by wireless temperature transmitters every 15 min for 1 hour. (B) The drop in core temperature between 0 min pre-injection and 30 min post-injection was calculated from the experiment shown in panel A. n = 6 mice per group. n.s.: P>0.05, t-test.