Carvacrol-induced hypothermia is associated with a decrease in whole-body energy production.

<p>Whole-body heat production was calculated from oxygen consumption (indirect calorimetry) measured in a metabolic chamber. Mice were injected intraperitoneally with vehicle or carvacrol at 31.6 mg/kg at time 0. N = 6 mice per group in a within-subject design. (A) and (C) Time course of core temperature (A) and heat production measurements (C). * P<0.05 at respective time points, 2-way Repeated Measures ANOVA/Holm-Sidak post-hoc test. (B) and (D) Change in core temperature (B) and heat production (D) from 0 min pre-injection to 30 min post-injection. * P<0.05, t-test.