Carvacrol delivered intravenously induces an acute drop in blood pressure in anesthetized mice.

<p>(A) Representative time course graphs showing the effects of a range of doses of carvacrol delivered intraperitoneally (IP) and intravenously (IV) on blood pressure of anesthetized CD-1 mice with stably maintained normal core temperature; PBS: phosphate-buffered saline (IV), used a negative control; PE: phenylephrine, 50 μg/kg IV, used as a validation control for reliable measurements of changes in blood pressure; Carv: carvacrol. (B) The relative change between pre-treatment (calculated as an average over 1 min prior to injection) and post-treatment (an average over 3 min after injection) blood pressure levels after respective treatments. Sol.: Solutol. n = 5 mice in a within-subject design. * P<0.05, one-sample t-test with a hypothesized mean of zero as the null hypothesis (i.e. no change in blood pressure); § P<0.05 vs PBS, t test; # P<0.05 vs Solutol IP, one-way ANOVA/Student-Newman-Keuls test.