Maternal hepatic NLRP3 inflammasome and inflammatory signalling.

<p>Offspring NLRP3 inflammasome and IL-1β mRNA levels at 2 timepoints. Data are presented as means ± S.E.M. All mRNA levels are relative to the geometric mean of housekeeping genes. Two-Way ANOVA Main Effects are indicated in text where the 2 factors are maternal diet (fructose) and offspring sex. Tukey’s <i>post-hoc</i> analyses are indicated by letters, where bars with different letters indicate significance p < 0.05. Control offspring are in open bars, fructose exposed offspring are in black bars. E21: embryonic day 21, P10: postnatal day 10. n = 6 per group per sex. NLRP3: NOD-like receptor family, pyrin domain containing 3, IL1β: interleukin 1 beta.